Metoprolol Tablets

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Therapeutic Indication

Hypertension (high blood pressure)
Angina pectoris (chest pain)
Heart failure (stable, chronic)
Arrhythmias (irregular heartbeat)
Secondary prevention post-myocardial infarction
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Metoprolol

Tablet

Metoprolol Succinate Extended Release is a cardioselective beta‑1 blocker. It reduces heart rate, cardiac output, and blood pressure, providing effective control in hypertension, angina, arrhythmias, and heart failure. The extended release formulation ensures once‑daily dosing with sustained therapeutic effect.

Speciality Cardiology | Internal Medicine
Tags Beta-Blocker | Hypertension | Angina | Heart Failure | Arrhythmia
Strength
  • Metoprolol Prolonged Release 25 mg/50 mg
  • Metoprolol Extended Release 100 mg
Packing Size
  • 10 Tablets

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Mechanism

Metoprolol selectively blocks beta‑1 adrenergic receptors in the heart, reducing sympathetic stimulation. This decreases heart rate, myocardial contractility, and oxygen demand, improving cardiac efficiency and lowering blood pressure.

Pharmacokinetics

  • Absorption: Well absorbed orally; extended release ensures sustained plasma levels.
  • Distribution: Widely distributed; ~12% protein bound.
  • Metabolism: Extensively metabolized in the liver via CYP2D6.
  • Elimination: Excreted in urine as metabolites.
  • Half-life: ~3–7 hours, prolonged with ER formulation.

Side Effects

  • Bradycardia
  • Fatigue
  • Dizziness
  • Hypotension
  • Rare: Depression, bronchospasm

Contraindication

  • Severe bradycardia
  • Heart block greater than first degree
  • Cardiogenic shock
  • Severe hypotension

Interaction

  • Other antihypertensives (additive effect)
  • Digoxin (increased risk of bradycardia)
  • CYP2D6 inhibitors (increase plasma levels)

Warning and Precautions

  • Do not discontinue abruptly (risk of rebound hypertension/angina)
  • Monitor heart rate and blood pressure regularly
  • Caution in asthma/COPD patients

Dosage

As directed by the Physician.

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.